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M9470135.TXT
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1994-07-02
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Document 0135
DOCN M9470135
TI Could oxidative stress initiate programmed cell death in HIV infection?
A role for plant derived metabolites having synergistic antioxidant
activity.
DT 9409
AU Greenspan HC; Arouma O; LGD Biomedical Group, Annandale, NJ 08801.
SO Chem Biol Interact. 1994 Jun;91(2-3):187-97. Unique Identifier :
AIDSLINE MED/94251845
AB Evidence supports the premise that a pro-oxidant condition exists in
HIV-seropositive patients, a result of an overabundance in production of
reactive oxygen forms combined with a multilevel deficiency in
nutritional and metabolic sources of antioxidants. Apoptosis (a
programmed cell death) is recognized as a possible pathway of immune
cell loss in patients with HIV infection and AIDS. The cascade of events
that results from 'oxidative stress' (OS) is markedly similar to that
which can initiate apoptosis and includes oxidation of cellular
membranes, alteration of metabolic pathways, disruption of electron
transport systems, depletion of cellular ATP production, loss of Ca2+
homeostasis, endonuclease activation and DNA/chromatin fragmentation.
Downstream events secondary to these effects may also play a role in
activation of latent virus and subsequent viral replication. Primary and
secondary metabolites found in plants act as synergistic antioxidants,
and can protect plants from oxidation-induced cell death. Experiments
have shown that some of these same metabolites can inhibit cell killing
by HIV. Can these compounds be useful in inhibiting viral activation and
the death of immune cells in HIV/AIDS through their synergistic
antioxidant properties? A brief review of the evidence for OS in HIV is
presented and the potential basis for OS playing a role in the
initiation of cell death and viral replication is explored. The
functional antioxidant activities of plant metabolites are illustrated
and the use of these synergistic antioxidants from plants are proposed
as a mechanism by which viral replication and cell killing in HIV
infection can be inhibited.
DE Antioxidants/METABOLISM/*PHARMACOLOGY *Apoptosis Calcium/METABOLISM
DNA Damage Homeostasis Human HIV Infections/*METABOLISM/PATHOLOGY
Lipid Peroxidation Plants/*CHEMISTRY Reactive Oxygen Species/*ADVERSE
EFFECTS JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).